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Gene Expression Data
Assay Details
Assay
Reference: J:199191 Rogers N, et al., Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expr Patterns. 2013 Oct;13(7):240-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6436562
Gene symbol: Sox3
Gene name: SRY (sex determining region Y)-box 3
Results
Specimen 1A: embryonic day 14.5 (more )
Note: Double labeled: red - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted 1A Expression in dorso-lateral and medial telencephalon.
TS22: diencephalon Present Regionally restricted 1A Expression in developing hypothalamus in ventral diencephalon.
Specimen 1B: embryonic day 12.5 (more )
Note: Triple labeled: red - Sox3; green - Sox2 (assay MGI:6436563); blue - DAPI.
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 1B Expression in pseudostratified neuroepithelium extensively co-localized with that of Sox2 within dorsal telencephalic vesicles.
Specimen E12.5 not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted Expression co-localized with that of Pax6 within dorsal telencephalic vesicles.
Specimen 1C: embryonic day 14.5 (more )
Note: Triple labeled: red - Sox3; green - Pax6 (assay MGI:6436564); blue - DAPI.
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted 1C Expression restricted to ventricular zone co-localized with that of Pax6 within dorsal telencephalic vesicles.
Specimen 1D: embryonic day 14.5 (more )
Note: Triple labeled: red - Sox3; green - RC2 (Nes assay MGI:6436565); blue - DAPI.
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted 1D Expression co-localized with that of RC2 (Nes) within dorsal telencephalic vesicles.
Specimen S1A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted S1A Expression in dorsal telencephalic vesicles. Expression overlapped with that of Sox2.
Specimen E14.5 not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted Authors report that expression overlapped with that of Mki67 and BLBP (Fabp7).
Specimen 1E: embryonic day 14.5 (more )
Note: Triple labeled: red - Sox3; green - Tubb3 (assay MGI:6436568); blue - DAPI.
Structure Level Pattern Image Note
TS22: telencephalon ventricular layer Present Regionally restricted 1E Expression did not overlap with that of Tubb3 within dorsal telencephalic vesicles.
Specimen 1F: embryonic day 18.5 (more )
Note: Double labeled: red - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS26: telencephalon ventricular layer Present Regionally restricted 1F Expression did not overlap with that of Tubb3 within dorsal telencephalic vesicles.
Specimen 2A: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Sox2 (assay MGI:6436563); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Widespread 2A Expression dispersed throughout subgranular zone.
Specimen 2A': postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Sox2 (assay MGI:6436563); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2A' Many expressing cells also express Sox2.
Specimen 2B/D: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Mki67 (assay MGI:6436566); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2D , 2B Some expressing cells overlap with cells expressing Mki67 in subgranular layer of dentate gyrus.
Specimen 2E/G: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Gfap (assay MGI:6436569); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2E , 2G Large cohort of expressing cells also express Gfap. Expression in radially projecting cells of subgranular layer of dentate gyrus.
Specimen 2H: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Nes (assay MGI:6436570); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2H Large cohort of expressing cells also express Nes. Expression in radially projecting neurons.
Specimen 2I: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Dcx (assay MGI:6436571); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2I Expression not co-localizing with Dcx within any cells of dentate gyrus.
Specimen 2J: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Dcx (assay MGI:6436571); blue - DAPI.
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Regionally restricted 2J Expression not co-localizing with Dcx within any cells of dentate gyrus.
Specimen 3A/C: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Sox2 (assay MGI:6436563); blue - DAPI.
Structure Level Pattern Image Note
TS28: telencephalon subventricular zone Present Regionally restricted 3A , 3C Expression within subventricular layer of lateral ventricles in subset of Sox2-expressing cells.
Specimen 3D: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Nes (assay MGI:6436570); blue - DAPI.
Structure Level Pattern Image Note
TS28: telencephalon subventricular zone Present Regionally restricted 3D Co-localization of expression with Nes within subventricular zone of lateral ventricles.
Specimen 3E: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - Dcx (assay MGI:6436571); blue - DAPI.
Structure Level Pattern Image Note
TS28: telencephalon subventricular zone Present Regionally restricted 3E Expression not co-localizing with Dcx in any cells of lateral ventricles.
Specimen 3F: postnatal adult (more )
Note: Triple labeled: red - Sox3; green - NeuN (Rbfox3 assay MGI:6436572); blue - DAPI.
Structure Level Pattern Image Note
TS28: telencephalon subventricular zone Present Regionally restricted 3F Expression not co-localizing with NeuN (Rbfox3) in any cells of lateral ventricles.
Specimen E10.5 not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted Expression in majority of cells in prospective hypothalamus, including periluminal stem/progenitors and infundibulum.
Specimen E11.5 not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted Expression in majority of cells in prospective hypothalamus, including periluminal stem/progenitors and infundibulum.
Specimen 4A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 4A Expression across entire anterior-posterior extent of presumptive hypothalamus.
Specimen 4B: embryonic day 14.5 (more )
Note: Triple labeled: green - Sox3; red - Calb1 (assay MGI:6436573); blue - DAPI.
Structure Level Pattern Image Note
TS22: hypothalamus Present Regionally restricted 4B Expression across entire anterior-posterior extent of presumptive hypothalamus. Co-expression with Calb1 in subset of cells with stronger Sox3 expression.
Specimen 4C/E: embryonic day 12.5 (more )
Note: Triple labeled: red - Sox3; green - Tubb3 (assay MGI:6436568); blue - DAPI.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted 4E , 4C High degree of overlap with expression of Tubb3 in ventrolateral hypothalamus. Majority of expressing cells did not express Tubb3 at this stage.
Specimen 4G/H: embryonic day 14.5 (more )
Note: Double labeled: green - Sox3; red - Tubb3 (assay MGI:6436568).
Structure Level Pattern Image Note
TS22: diencephalon Present Regionally restricted 4H , 4G Partial overlap with expression of Tubb3 within rostral diencephalon. Many expressing cells located in lateral Tubb3 domain.
Specimen 4J: embryonic day 12.5 (more )
Note: Double labeled: green - Sox3; red - Mki67 (assay MGI:6436566).
Structure Level Pattern Image Note
TS20: brain Present Regionally restricted 4J Strongly expressing cells have little overlap with Mki67 expression.
Specimen 4L: embryonic day 12.5 (more )
Note: Double labeled: green - Sox3; red - Sox2 (assay MGI:6436563).
Structure Level Pattern Image Note
TS20: brain Present Regionally restricted 4L Co-localization with Sox3 along edge of 3rd ventricle. Little overly of expression in lateral region.
Specimen 4M: embryonic day 14.5 (more )
Note: Double labeled: green - Sox3; red - Calb1 (assay MGI:6436573).
Structure Level Pattern Image Note
TS22: hypothalamus Present Regionally restricted 4M Co-expression with Calb1 in subset of cells with stronger Sox3 expression.
Specimen 4N: embryonic day 14.5 (more )
Note: Double labeled: green - Sox3; red - Calb1 (assay MGI:6436573).
Structure Level Pattern Image Note
TS22: hypothalamus Present Regionally restricted 4N Co-expression with Calb1 in subset of cells with stronger Sox3 expression.
Specimen 4P/Q: embryonic day 14.5 (more )
Note: Double labeled: green - Sox3; red - Sox2 (assay MGI:6436563).
Structure Level Pattern Image Note
TS22: hypothalamus Present Regionally restricted 4Q , 4P Strongly expressing cells have little overlap with Mki67 expression.
Specimen 5A: postnatal day 21 (more )
Note: Double labeled: green - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: hypothalamus Present 5A
Specimen 5B: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: ventromedial hypothalamic nucleus Present 5B
Specimen 5C: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: hypothalamus Present Regionally restricted 5C Expression within distinct region of hypothalamus.
Specimen 5D/E: postnatal day 21 (more )
Note: Double labeled: green - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present 5E , 5D
Specimen 5F/G: postnatal day 21 (more )
Note: Double labeled: green - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: arcuate nucleus Present 5F , 5G
Specimen S4A/B: postnatal adult (more )
Note: Double labeled: red - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: main olfactory bulb Present S4A/B
Specimen S4C/D: postnatal adult (more )
Note: Double labeled: red - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: cerebral cortex Present S4C/D
Specimen S4E/F: postnatal adult (more )
Note: Double labeled: red - Sox3; blue - DAPI.
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present S4E/F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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