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Gene Expression Data
Assay Details
Assay
Reference: J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6416417
Gene symbol: Pou3f3
Gene name: POU domain, class 3, transcription factor 3
Results
Specimen 4S: embryonic day 17.5 (more )
Note: The genetic background of the conditional control specimen was not specified. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 4S Expression was detected in Ammon's horn pyramidal cell layer.
Specimen 4T: embryonic day 17.5; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS25: hippocampus Present Regionally restricted 4T The labeling in Ammon's horn pyramidal cell layer was much smaller in the mutant.
Specimen 8I: postnatal day 0; Nf2tm2Gth/Nf2+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Control specimen. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present 8I
Specimen 8J: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present 8J The labeled area was much smaller in the mutant.
Specimen 8K: postnatal day 0; Nf2tm2Gth/Nf2+, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present 8K
Specimen 8L: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present 8L
Specimen 8M: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present 8M In six out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the Ammon's horn appeared identical to those in control (8I) brains.
Specimen S9B: postnatal day 0; Nf2tm2Gth/Nf2tm2Gth, Yap1tm1.1Eno/Yap1tm1.1Eno, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - Pou3f3; green - Zbtb20 (assay MGI:6416323).
Structure Level Pattern Image Note
TS27: hippocampus pyramidal cell layer Present S9B In four out of ten Nf2<F/F>;Yap<F/F>;Emx1-Cre hippocampi, the Ammon's horn showed partial rescue of the defects due to the Nf2 mutation.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory