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Gene Expression Data
Assay Details
Assay
Reference: J:224632 Lowe KL, et al., Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood. 2015 Jun 11;125(24):3769-77
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6407113
Gene symbol: Cspg4
Gene name: chondroitin sulfate proteoglycan 4
Antibody: anti-NG2 (clone 132.39)
Detection system: Secondary antibody
Results
Specimen 4A +/+: embryonic day 11.5 (more )
Note: Triple labeled: blue - Cspg4; green - Pecam1 (assay MGI:6407096); red - Pdpn (assay MGI:6407082).
Structure Level Pattern Image Note
TS19: brain blood vessel Present Regionally restricted 4A +/+ merge , 4A +/+ NG2 Expressed in pericytes.
Specimen 4A Clec-2-/-: embryonic day 11.5; Clec1btm1.2Arte/Clec1btm1.2Arte (more )
Note: Triple labeled: blue - Cspg4; green - Pecam1 (assay MGI:6407096); red - Pdpn (assay MGI:6407082).
Structure Level Pattern Image Note
TS19: brain blood vessel Present Regionally restricted 4A Clec-2-/- merge , 4A Clec-2-/- NG2 Reduced number of positve pericytes compared with littermates.
Specimen 4A Pdpn PGK-cKO: embryonic day 11.5; Pdpntm1Arte/Pdpntm1Arte, Tg(Pgk1-cre)1Lni/0 (more )
Note: Conditional mutant. Triple labeled: blue - Cspg4; green - Pecam1 (assay MGI:6407096); red - Pdpn (assay MGI:6407082).
Structure Level Pattern Image Note
TS19: brain blood vessel Present Regionally restricted 4A Pdpn PGK cKO NG2 , 4A Pdpn PGK cKO merge Reduced number of positve pericytes compared with littermates.
Specimen 4A Pdpn Nes-cKO: embryonic day 11.5; Pdpntm1Arte/Pdpntm1Arte, Tg(Nes-cre)1Wmz/0 (more )
Note: Conditional mutant. Triple labeled: blue - Cspg4; green - Pecam1 (assay MGI:6407096); red - Pdpn (assay MGI:6407082).
Structure Level Pattern Image Note
TS19: brain blood vessel Present Regionally restricted 4A Pdpn Nes cKO merge , 4A Pdpn Nes cKO NG2 Reduced number of positve pericytes compared with littermates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory