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Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400921
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Antibody: anti-Tubb3
Results
Specimen S2C control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Tubb3; magenta - Casp3 (assay MGI:6400589).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted S2C ctrl Expression was detected in immature and mature neurons. 0% of the Tubb3+ cells were nonpyknotic cleaved Casp3+.
Specimen S2C mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Tubb3; magenta - Casp3 (assay MGI:6400589).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted S2C mut In the E12 mutant pallium, the vast majority (93.4%) of the cleaved Casp3+ cells were pyknotic. Of the nonpyknotic Casp3+ cells, 4.44% were Tubb3-immunopositive, which was not significantly higher than the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory