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Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400919
Gene symbol: Pax6
Gene name: paired box 6
Results
Specimen 4F left: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Pax6; magenta - H2ax (assay MGI:6400789).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 4F Pax6 46.3% of H2ax-immunopositive cells in the mutant pallium were also Pax6-immunopositive radial glial cells.
Specimen 5D control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5D E12 ctrl Expression was detected in radial glial cells.
Specimen 5D mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Pax6; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5D E12 mut A significantly higher percentage of mitotic Aurkb+/Pax6+ radial glial cells were in prometaphase+metaphase in the E12 mutant pallium than in the control. Prophase, anaphase, and telophase cells were not significantly different compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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