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Gene Expression Data
Assay Details
Assay
Reference: J:266583 Baumgartner M, et al., Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6400773
Gene symbol: Eomes
Gene name: eomesodermin
Results
Specimen 3I control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 3I control Expression was detected in intermediate progenitor cells.
Specimen 3I mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 3I mutant The number of immunopositive intermediate progenitor cells was not changed in the E12 mutant pallium.
Specimen 3J control: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted 3J control Expression was detected in intermediate progenitor cells.
Specimen 3J mutant: embryonic day 13.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted 3J mutant At E13 the number of immunopositive intermediate progenitor cells was significantly reduced in the mutant pallium.
Specimen 3K control: embryonic day 14.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: neocortex Present Regionally restricted 3K control Expression was detected in intermediate progenitor cells.
Specimen 3K mutant: embryonic day 14.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: neocortex Present Regionally restricted 3K mutant At E14 the number of immunopositive intermediate progenitor cells was significantly reduced in the mutant pallium.
Specimen 4F middle: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Eomes; magenta - H2ax (assay MGI:6400789).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 4F Tbr2 Expression was detected in intermediate progenitor cells in the E12 mutant pallium. There was no co-expression with H2ax.
Specimen 5H control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Eomes; magenta - EdU.
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5H E12 ctrl Expression was detected in intermediate progenitor cells.
Specimen 5H mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Eomes; magenta - EdU.
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 5H E12 mut There was no significant difference in the percentage of EdU+/Tbr2+ intermediate progenitor cells in the mutant pallium compared to control.
Specimen S4B control: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Eomes; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted S4B ctrl Expression was detected in intermediate progenitor cells.
Specimen S4B mutant: embryonic day 12.5; Rnu11tm1.1Rank/Rnu11tm1.1Rank, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: magenta - Eomes; green - Aurkb (assay MGI:6400916).
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted S4B mut There were no significant differences in the fractions of mitotic intermediate progenitor cells in the mutant pallium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
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