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Mlklem1Mpa
Endonuclease-mediated Allele Detail
Summary
Symbol: Mlklem1Mpa
Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Manolis Pasparakis
MGI ID: MGI:6392916
Gene: Mlkl  Location: Chr8:112038429-112064809 bp, - strand  Genetic Position: Chr8, 57.98 cM, cytoband D3
Alliance: Mlklem1Mpa page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: CRISPR/Cas9 genome editing technology was used to generate a mutation in exon 2 downstream of the ATG of the gene. (J:242991)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mlkl Mutation:  31 strains or lines available
References
Original:  J:242991 Lin J, et al., RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 01;540(7631):124-128
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory