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Gene Expression Data
Assay Details
Assay
Reference: J:206581 Bowles J, et al., Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6303621
Gene symbol: Prox1
Gene name: prospero homeobox 1
Results
Specimen 2B: embryonic day 11.5 (more )
Note: Double labeled: red - Prox1; blue - Cyp26b1 (assay MGI:6303607).
Structure Level Pattern Image Note
TS19: lymphatic system Present Regionally restricted 2B Authors report expression near lymphatic endothelial cell (LEC) progenitors.
Specimen 3A: embryonic day 11.5 (more )
Note: Double labeled: red - Prox1; green - Pdpn (assay MGI:6303622).
Structure Level Pattern Image Note
TS19: cardinal vein Present Regionally restricted 3A Expression in LEC progenitors organized along the anterior-posterior axis of the cardinal vein.
Specimen 3B: embryonic day 11.5; Cyp26b1tm1Hmd/Cyp26b1tm1Hmd (more )
Note: Double labeled: red - Prox1; green - Pdpn (assay MGI:6303622).
Structure Level Pattern Image Note
TS19: cardinal vein Present Regionally restricted 3B Expression in LEC progenitors is expanded in mutants compared to wild type embryos.
Specimen 3G/H: embryonic day 11.5 (more )
Note: Double labeled: red - Prox1; blue - Lyve1 (assay MGI:6303623).
Structure Level Pattern Image Note
TS19: lymph sac Present 3H , 3G
Specimen 3J/K: embryonic day 11.5; Cyp26b1tm1Hmd/Cyp26b1tm1Hmd (more )
Note: Double labeled: red - Prox1; blue - Lyve1 (assay MGI:6303623).
Structure Level Pattern Image Note
TS19: lymph sac Present Regionally restricted 3J , 3K Authors report enlarged lymph sacs in mutatnt embryos complared to wild type embryos.
Specimen 5D/F: embryonic day 13.5 (more )
Note: Triple labeled: red - Prox1; green - Foxc2 (assay MGI:6303625); blue - Lyve1 (assay MGI:6303623).
Structure Level Pattern Image Note
TS21: vascular system Present Regionally restricted 5D , 5F High levels of expression in lymphovenous valves separating jugular and subclavian veins from jugular lymph sacs.
Specimen 5H/J: embryonic day 13.5; Cyp26b1tm1Hmd/Cyp26b1tm1Hmd (more )
Note: Triple labeled: red - Prox1; green - Foxc2 (assay MGI:6303625); blue - Lyve1 (assay MGI:6303623).
Structure Level Pattern Image Note
TS21: vascular system Present Regionally restricted 5H , 5J Lymphovenous valves expanded in size.
Specimen 6E: embryonic day 14.5 (more )
Note: Triple labeled: red - Prox1; green - Pdpn (assay MGI:6303622); blue - Pecam1 (assay MGI:6303624).
Structure Level Pattern Image Note
TS22: lymph sac Present 6E
Specimen S2A: embryonic day 11.5 (more )
Note: Double labeled: red - Prox1; blue - Vegfr3 (Flt4 assay MGI:6303627).
Structure Level Pattern Image Note
TS19: cardinal vein Present S2A
Specimen S2B: embryonic day 11.5; Cyp26b1tm1Hmd/Cyp26b1tm1Hmd (more )
Note: Double labeled: red - Prox1; blue - Vegfr3 (Flt4 assay MGI:6303627).
Structure Level Pattern Image Note
TS19: cardinal vein Present Regionally restricted S2B Authors report ectopic distribution of LEC precursors throughout both dorso-lateral and ventro-medial aspects of cardinal vein.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory