Megf10tm1c(KOMP)Jrs
Targeted Allele Detail
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| Symbol: |
Megf10tm1c(KOMP)Jrs |
| Name: |
multiple EGF-like-domains 10; targeted mutation 1c, Joshua R Sanes |
| MGI ID: |
MGI:6194031 |
| Synonyms: |
Megf10flox, Megf10tm1c |
| Gene: |
Megf10 Location: Chr18:57266162-57430539 bp, + strand Genetic Position: Chr18, 31.5 cM
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| Alliance: |
Megf10tm1c(KOMP)Jrs page
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutation: |
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Insertion
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Mutation details: The targeting cassette obtained from KOMP is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:263281)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Megf10 Mutation: |
69 strains or lines available
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| Original: |
J:263281 Ray TA, et al., Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact. Elife. 2018 Apr 3;7:e34241 |
| All: |
4 reference(s) |
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Analysis Tools
