Megf10tm1b(KOMP)Jrs
Targeted Allele Detail
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| Symbol: |
Megf10tm1b(KOMP)Jrs |
| Name: |
multiple EGF-like-domains 10; targeted mutation 1b, Joshua R Sanes |
| MGI ID: |
MGI:6194030 |
| Synonyms: |
Megf10lacZ |
| Gene: |
Megf10 Location: Chr18:57266162-57430539 bp, + strand Genetic Position: Chr18, 31.5 cM
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| Alliance: |
Megf10tm1b(KOMP)Jrs page
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The targeting cassette obtained from KOMP is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4. The critical exon 4 is thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:182578)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Megf10 Mutation: |
69 strains or lines available
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| Original: |
J:182578 Kay JN, et al., MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature. 2012 Mar 22;483(7390):465-9 |
| All: |
5 reference(s) |
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Analysis Tools
