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Gene Expression Data
Assay Details
Assay
Reference: J:121343 Lahteenmaki M, et al., Increased apoptosis of parasympathetic but not enteric neurons in mice lacking GFRalpha2. Dev Biol. 2007 May 1;305(1):325-32
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6161697
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-activated caspase 3
Detection system: Cy3
Results
Specimen 5a: embryonic day 17.5 (more )
Note: Triple labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683); blue - Hoechst 33258.
Structure Level Pattern Image Note
TS25: myenteric nerve plexus Absent 5a No expression in myenteric neurons.
Specimen 5b: embryonic day 17.5 (more )
Note: Triple labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683); blue - Hoechst 33258.
Structure Level Pattern Image Note
TS25: paravertebral ganglion Present Regionally restricted 5b Expression in neurons of paravertebral sympathetic ganglia.
Specimen 5d/f: embryonic day 17.5 (more )
Note: Triple labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683); blue - Hoechst 33258.
Structure Level Pattern Image Note
TS25: pancreas Present Regionally restricted 5f , 5d Expression in neurons with pyknotic nuclei in intrapancreatic ganglia.
TS25: parasympathetic ganglion Present Regionally restricted 5f , 5d Expression in neurons with pyknotic nuclei in intrapancreatic ganglia.
Specimen 5h/j: embryonic day 17.5; Gfra2tm1Msa/Gfra2tm1Msa (more )
Note: Triple labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683); blue - Hoechst 33258.
Structure Level Pattern Image Note
TS25: pancreas Present Regionally restricted 5h , 5j Expression in neurons with pyknotic nuclei in intrapancreatic ganglia.
TS25: parasympathetic ganglion Present Regionally restricted 5h , 5j Expression in neurons with pyknotic nuclei in intrapancreatic ganglia.
Specimen 5k/m: postnatal day 0; Gfra2tm1Msa/Gfra2tm1Msa (more )
Note: Triple labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683); blue - Hoechst 33258.
Structure Level Pattern Image Note
TS27: submandibular ganglion Present Regionally restricted 5m , 5k Expression marks apoptotic cells.
Specimen Supplementary Figure b: embryonic day 15.5 (more )
Note: Double labeled: red - activated caspase-3 (Casp3); green - PGP9.5 (Uchl1 assay MGI:6161683).
Structure Level Pattern Image Note
TS23: dorsal root ganglion Present Regionally restricted Supplementary_b activated caspase-3 , Supplementary_b merge Authors report expression in PGP9.5 (Uchl1) positive cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory