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Gene Expression Data
Assay Details
Assay
Reference: J:141643 Montano MM, et al., Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5817397
Gene symbol: Hexim1
Gene name: hexamethylene bis-acetamide inducible 1
Reporter: lacZ
Direct Detection
Results
Specimen 2A left: embryonic day 11.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS19: embryo Present Regionally restricted 2A left
Specimen 2A right: embryonic day 11.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS19: cardiac muscle tissue Present 2A right Expression in myocardium.
TS19: outflow tract endocardial cushion Present Regionally restricted 2A right Expression in endothelial lining of endocardial cushions of outflow tract.
TS19: atrioventricular canal endocardial lining Absent 2A right No expression in endothelial lining of endocardial cushions of atrioventricular junction.
Specimen 2B left: embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS25: heart Present Regionally restricted 2B left Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
Specimen 2B left inset: embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS25: cardiac muscle tissue Present 2B left inset Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
TS25: endocardial lining Present 2B left inset Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
TS25: visceral pericardium Present 2B left inset Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
Specimen 2B right: embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Structure Level Pattern Image Note
TS25: aorta Present 2B right Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
TS25: pulmonary artery Present 2B right Authors report expression in aorta, pulmonary arteries, epicardium, myocardium, inner trabeculae, and endothelium of the endocardial lining.
Specimen S1B beta-gal (upper): embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Note: Double labeled: green - Hexim1 reporter; red sarcomeric actin.
Structure Level Pattern Image Note
TS25: cardiac muscle tissue Present S1B overlay (upper) , S1B beta-gal (upper) Authors report co-expression with marker for myocardial cells.
Specimen S1B beta-gal (middle): embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Note: Double labeled: red - Hexim1 reporter; green - cytokeratin 18 (Krt18 assay MGI:5817415).
Structure Level Pattern Image Note
TS25: visceral pericardium Present S1B overlay (middle) , S1B beta-gal (middle) Authors report co-expression with marker for epicardial cells.
Specimen S1B beta gal (lower): embryonic day 17.5; Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg (more )
Note: Double labeled: red - Hexim1 reporter; green - Pecam1 (assay MGI:5817410).
Structure Level Pattern Image Note
TS25: endocardial lining Present Regionally restricted S1B beta-gal (lower) , S1B overlay (lower) Authors report co-expression with marker for endocardial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory