Phenotypes for Ephb1 MGI:5767281 MGI Mouse

abnormal axon fasciculation ( J:214959 )

• internal capsule defasciculation at P28

• at P28, cortical neurons aberrantly project through the anterior commissure, unlike in wild-type brains

• ectopic axon bundles extend within the internal capsule toward the external capsule and continue to grow ventrally

• high-angular-resolution diffusion imaging (HARDI) tractography confirmed that axon fibers in dorsal areas of the neocortex merge with the anterior commissure, unlike in wild-type brains

• however, class-specific identity and distribution of cortical projection neurons is unaltered

increased anterior commissure size ( J:214959 )

• expansion of the anterior commissure at P28

increased brain external capsule size ( J:214959 )

• expansion of the brain external capsule at P28

abnormal brain internal capsule morphology ( J:214959 )

• at P28, the internal capsule contains smaller than wild type and partly unfasciculated axon bundles

decreased brain internal capsule size ( J:214959 )

• internal capsule reduction at P28

abnormal somatosensory cortex morphology ( J:214959 )

• at P2, DiI anterograde injections in deep layers of the somatosensory cortex revealed axons ectopically crossing at the anterior commissure and extending ventrally and rostrally, unlike in wild-type mice