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Phenotypes Associated with This Genotype
Genotype
MGI:5688385
Allelic
Composition
Ccnyl1tm1a(EUCOMM)Wtsi/Ccnyl1tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6N
Cell Lines EPD0177_5_F06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnyl1tm1a(EUCOMM)Wtsi mutation (2 available); any Ccnyl1 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal fertility
• many sperm exhibit heads that are bent and wrapped around the next
• spermatozoa from the cauda epididymis lack cytoplasmic droplets
• however, capacitation ability is intact
• thinning
• with a sharp bend in half of spermatozoa
• at the thinned annulus region
• progressive spermatozoa exhibit reduced velocity compared with wild-type cells
• total and progressive spermatozoa motility is reduced compared with wild-type cells
• male sterility
• impaired ability of sperm to fertilize oocyte in vitro

cellular
• many sperm exhibit heads that are bent and wrapped around the next
• spermatozoa from the cauda epididymis lack cytoplasmic droplets
• however, capacitation ability is intact
• thinning
• with a sharp bend in half of spermatozoa
• at the thinned annulus region
• progressive spermatozoa exhibit reduced velocity compared with wild-type cells
• total and progressive spermatozoa motility is reduced compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory