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Gene Expression Data
Assay Details
Assay
Reference: J:139010 MacDonald JL, et al., Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev Dyn. 2008 Aug;237(8):2256-67
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5566902
Gene symbol: Pcna
Gene name: proliferating cell nuclear antigen
Antibody: anti-PCNA
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1B/C: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS21: telencephalon Strong Graded 1B , 1C Highly expressed in proliferative cells around the lateral ventricle, with relative detection decreasing in cells further away.
TS21: midbrain Present Scattered 1C , 1B Only expressed in scattered cells. Not detected in most cells.
TS21: olfactory epithelium Present 1C , 1B Expressed in the proliferative olfactory epithelium.
Specimen 1D: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS21: olfactory lobe Present 1D Expressed in proliferative cells.
TS21: telencephalon Present 1D Expressed in proliferative cells.
Specimen 1H/I: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 1I , 1H Expressed in proliferative cells adjacent to the central canal.
Specimen 1N: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS21: hindbrain Present 1N Expressed in proliferative cells.
Specimen 2B/C: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS21: telencephalon Present Regionally restricted 2C , 2B Expressed in proliferating progenitors around the lateral ventricle.
TS21: cerebral cortex ventricular layer Present 2B , 2C Expressed in the proliferative ventricular zone.
Specimen 2E: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS21: neocortex Present Regionally restricted 2E Expressed in progenitors in the proliferative ventricular and subventricular zones.Expressed in progenitors in the proliferative ventricular and subventricular zones.
Specimen 2G: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS21: telencephalon Present 2G Expressed in proliferative cells.
Specimen 2L/M: embryonic day 13.5 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS21: spinal cord Present 2L , 2M Expressed in proliferative cells.
Specimen 3E: postnatal day 7 (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS28: dentate gyrus Present 3E Expressed in proliferative cells.
Specimen 4E: postnatal day 7 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS28: dentate gyrus Present 4E Expressed in proliferative cells.
Specimen 4I: postnatal day 7 (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 4I Expressed in proliferative cells.
Specimen 6D: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present 6D Expressed in actively cycling, PCNA-positive progenitors.
Specimen 6F: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 6F Expressed in cells of the subventricular zone of the lateral ventricle and the rostral migratory stream, which coexpressed PCNA.
TS28: telencephalon subventricular zone Present Regionally restricted 6F Expressed in cells of the subventricular zone of the lateral ventricle and the rostral migratory stream, which coexpressed PCNA.
Specimen 6G: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 6G Expressed in PCNA-positive cycling progenitors in the rostral migratory stream.
Specimen 6M: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac1 (assay MGI:5565614).
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted 6M Expressed along the subventricular zone of the lateral ventricle, in PCNA-positive mitotic progenitors.
Specimen 6R: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present 6R
Specimen 6W: postnatal adult (more )
Note: Double labeled: green - Pcna; red - Hdac2 (assay MGI:5565615).
Structure Level Pattern Image Note
TS28: rostral migratory stream Present Regionally restricted 6W Expressed in mitotic progenitors in the rostral migratory stream.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory