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Gene Expression Data
Assay Details
Assay
Reference: J:37125 Serafini T, et al., Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996 Dec 13;87(6):1001-14
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5461912
Gene symbol: Cntn2
Gene name: contactin 2
Antibody: anti-TAG-1 (4D7)
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube Present 3A Expression is in commissural neurons.
TS19: neural tube floor plate Present 3A
Specimen 3B: embryonic day 11.5; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Structure Level Pattern Image Note
TS19: neural tube Present 3B Expression is in commissural neurons and growth is disorganized in this mutant and few neurons reach the floor plate.
Specimen 3C: embryonic day 11.5; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Structure Level Pattern Image Note
TS19: neural tube Present 3C Expression is in commissural neurons and growth is disorganized in this mutant and few neurons reach the floor plate.
Specimen Not shown +/-: embryonic day 11.5; Ntn1Gt(ST629)Byg/Ntn1+ (more )
Structure Level Pattern Image Note
TS19: neural tube Present Regionally restricted Expression is in commissural neurons.
TS19: neural tube floor plate Present
Specimen 3D: embryonic day 10.5; Ntn1Gt(ST629)Byg/Ntn1+ (more )
Note: Double labeled: red - Cntn2; green - Ntn1 (assay MGI:5461937).
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 3D
Specimen 3E: embryonic day 10.5; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Note: Double labeled: red - Cntn2; green - Ntn1 (assay MGI:5461937).
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 3E Commissural axons display defective trajectories in this mutant; none have reached the floor plate, and some appear to have turned to grow toward the ventricle.
Specimen 4A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube Present 4A
TS19: neural tube floor plate Present 4A
Specimen 4B: embryonic day 11.5; Ntn1Gt(ST629)Byg/Ntn1+ (more )
Structure Level Pattern Image Note
TS19: neural tube Present 4B
TS19: neural tube floor plate Present 4B
Specimen 4C: embryonic day 11.5; Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg (more )
Structure Level Pattern Image Note
TS19: neural tube Present Regionally restricted 4C The expression that is observed is disorganized when compared to that seen in wild-type or hetrozygote littermates.
TS19: neural tube floor plate Present Regionally restricted 4C The expression that is observed is disorganized when compared to that seen in wild-type or hetrozygote littermates.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory