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Gene Expression Data
Assay Details
Assay
Reference: J:155881 Bedogni F, et al., Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr Patterns. 2010 Jan;10(1):9-15
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5448144
Gene symbol: Auts2
Gene name: autism susceptibility candidate 2
Antibody: anti-Auts2
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1E: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Gfap (assay MGI:5448648).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 1E Expressed in neurons only (not in cells marked by Gfap).
Specimen 1F: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Rbfox3 (assay MGI:5448649).
Structure Level Pattern Image Note
TS28: cerebral cortex Present 1F Expressed in neurons only (marked by NeuN).
Specimen 4C: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Sox2 (assay MGI:5448676).
Structure Level Pattern Image Note
TS28: dentate gyrus subgranular zone Present Widespread 4C Expressed throughout the cell layer, but not in progenitor cells (marked by Sox2).
TS28: dentate gyrus granule cell layer Present Widespread 4C
Specimen 4D: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Pcna (assay MGI:5448683).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Widespread 4D Expressed throughout the cell layer.
TS28: dentate gyrus subgranular zone Present 4D Not expressed in dividing cells (marked by PCNA).
Specimen 4E: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Neurod1 (assay MGI:5448686).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Widespread 4E Expressed throughout the cell layer, colocalized with markers of immature neurons (NeuroD).
TS28: dentate gyrus subgranular zone Present Widespread 4E Expressed throughout the cell layer, colocalized with markers of immature neurons (NeuroD).
Specimen 4F: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Calb1 (assay MGI:5448674).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Widespread 4F Expressed throughout the cell layer, colocalized with marker of mature granule neurons at the outer margins (calbindin).
TS28: dentate gyrus subgranular zone Present Widespread 4F
Specimen 4G/G": postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Dcx (assay MGI:5448687).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Widespread 4G , 4G" Expressed throughout the cell layer, colocalized with markers of immature neurons (DCX).
TS28: dentate gyrus subgranular zone Present Widespread 4G , 4G" Expressed throughout the cell layer, colocalized with markers of immature neurons (DCX).
Specimen 4H/H": postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Calb2 (assay MGI:5448658).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Widespread 4H , 4H" Expressed throughout the cell layer, colocalized with markers of immature neurons (calretinin).
TS28: dentate gyrus subgranular zone Present Widespread 4H , 4H" Expressed throughout the cell layer, colocalized with markers of immature neurons (calretinin).
Specimen 5b: postnatal day 21 (more )
Note: Double labeled: green - Auts2; red - Calb1 (assay MGI:5448674).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 5b Colocalized with calbindin. Higher magnification was shown in the inset.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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