• dramatic increase in serum hyaluronic acid levels

• marked decrease in the internalization of hyaluronic acid in hepatic sinusoid endothelial cells indicating a defect in endocytosis

• 14 days after i.v. inoculation with B16F10 melanoma cells fewer black nodules form on the lung surface; however, tumor formation after subcutaneous inoculation with B16F10 melanoma cells does not differ from wild-type mice indicating a decrease in metastasis