Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcf7l2em1Nobr
Name:	transcription factor 7 like 2, T cell specific, HMG box; endonuclease-mediated mutation 1, Marcelo A Nobrega
MGI ID:	MGI:5292672
Synonyms:	Line 1
Gene:	Tcf7l2  Location: Chr19:55730252-55922086 bp, + strand  Genetic Position: Chr19, 51.59 cM
Alliance:	Tcf7l2em1Nobr page

Strain of Origin:

CD-1

Allele Type:    Endonuclease-mediated (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A zinc finger targeting exon 11 (using alternative exon 4 in exon numbering) induced a 1 bp deletion that results in alteration of the amino acids after codon 390 (TLAGLHGITMGRRRREKETSSRGKPTNTANVS) and introduction of a premature stop codon. (J:175874)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:	56 strains or lines available

Original:	J:175874 Savic D, et al., Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep;21(9):1417-25
All:	3 reference(s)