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Phenotypes Associated with This Genotype
Genotype
MGI:5285855
Allelic
Composition
Padi4tm1.1Kmow/Padi4tm1.1Kmow
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4tm1.1Kmow mutation (2 available); any Padi4 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• neutrophils lack histone deimination unlike wild-type cells
• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice
• however, influenza-infected mice exhibit normal survival, neutrophil recruitment into the lung, lung viral titers, and pro-inflammatory cytokine levels

growth/size/body
• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice

hematopoietic system
• neutrophils lack histone deimination unlike wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory