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Gene Expression Data
Assay Details
Assay
Reference: J:66508 Sakai R, et al., The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec;28(3):819-33
Assay type: Immunohistochemistry
MGI Accession ID: MGI:4867065
Gene symbol: Ntrk1
Gene name: neurotrophic tyrosine kinase, receptor, type 1
Antibody: Anti-TrkA
Detection system: Secondary antibody
Results
Specimen 5D WT: postnatal week 8 (more )
Note: Data presented in a graph of neuron number.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5D
Specimen 5D B/C: postnatal week 8; Shc2tm1Paw/Shc2tm1Paw, Shc3tm1Paw/Shc3tm1Paw (more )
Note: Data presented in a graph of neuron number.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5D The number of immunopositive neurons decreased in the double mutant.
Specimen 5D B: postnatal week 8; Shc2tm1Paw/Shc2tm1Paw (more )
Note: Data presented in a graph of neuron number.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5D The number of immunopositive neurons decreased in the ShcB mutant.
Specimen 5D C: postnatal week 8; Shc3tm1Paw/Shc3tm1Paw (more )
Note: Data presented in a graph of neuron number.
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5D The number of immunopositive neurons was not reduced in the ShcC mutant.
Specimen 5G: postnatal adult; Shc2tm1Paw/Shc2+, Shc3tm1Paw/Shc3+ (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5G
Specimen 5H: postnatal adult; Shc2tm1Paw/Shc2tm1Paw, Shc3tm1Paw/Shc3tm1Paw (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5H
Specimen 5I: postnatal adult; Shc2tm1Paw/Shc2tm1Paw (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5I
Specimen 5J: postnatal adult; Shc3tm1Paw/Shc3tm1Paw (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5J
Specimen 5O: postnatal adult; Shc3tm1Paw/Shc3+ (more )
Note: Double labeled: brown - Ntrk1; blue - Shc3 reporter (assay MGI:4867075).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5O ShcC does not strongly colocalize with TrkA; only ~15% of TrkA+ neurons also stained for ShcC.
Specimen 5P: postnatal adult; Shc3tm1Paw/Shc3+ (more )
Note: Double labeled: brown - Ntrk1; blue - Shc3 reporter (assay MGI:4867075).
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 5P ShcC does not strongly colocalize with TrkA; only ~15% of TrkA+ neurons also stained for ShcC.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory