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Phenotypes Associated with This Genotype
Genotype
MGI:3697610
Allelic
Composition
Acvr1tm1Bhr/Acvr1tm1Bhr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Bhr mutation (0 available); any Acvr1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• starting at E7-E7.5, embryos are much smaller

embryo
• at E7-7.5, embryos form empty sacs composed of parietal endoderm as the epiblast is forced into the proamniotic cavity
• mesoderm formation is initiated but the subsequent development is arrested during the mid-late streak stages
• at the mid-late streak stage
• starting at E7-E7.5, embryos are much smaller
• the posterior epiblast is forced into the proamniotic cavity by the thicker primitive streak
• thicker primitive streak that forces the posterior epiblast into to the proamniotic cavity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory