Analysis Tools
mortality/aging
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• homozygotes are underrepresented by P10 and none survive to weaning
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craniofacial
domed cranium
(
J:94631
)
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• fusion of the occipital sutures prevents longitudinal growth of the skull displacing the brain and producing a domed skull
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growth/size/body
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• by P10 mutants are severely runted
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skeleton
domed cranium
(
J:94631
)
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• fusion of the occipital sutures prevents longitudinal growth of the skull displacing the brain and producing a domed skull
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• by P2 hypertrophic chondrocytes are found in the chondrocostal cartilage of mutants but not in wild-type mice
• by P8 a mature ossification center is established and the hypertrophic chondrocytes are replace by trabeculated bone
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• the chondrocostal cartilage which normally does not ossify is almost completely ossified in mutants
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• pups have visibly deformed spines as a result of ossification defects
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• cartilaginous regions in the vertebrae and hyoid bones are completely ossified and premature mineralization was seen in the cartilage of all bones forming through endochondral ossification
• premature ossification can be seen by E18
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• the occipital sutures are ossified at P8
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nervous system
exencephaly
(
J:94631
)
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• a subset of mutants have exencephaly
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