Analysis Tools
cellular
|
• osteoblast proliferation is increased compared to in wild-type mice
|
craniofacial
|
• although normal at birth, mice develop craniofacial abnormalities beginning at P3
|
long incisors
(
J:63959
)
|
• mice exhibit facial asymmetry with anterio-posterior shortening, lateral widening and vertical heightening compared with wild-type mice
|
|
• mice exhibit midface hypoplasia compared with wild-type mice
|
skeleton
|
• osteoblast proliferation is increased compared to in wild-type mice
|
|
• although normal at birth, mice develop craniofacial abnormalities beginning at P3
|
long incisors
(
J:63959
)
|
• due to increased osteoblast proliferation
|
|
• at P16 to P21, mice exhibit premature fusion of the frontal, saggital, and coronal sutures unlike in wild-type mice
• lamboid and occipitointerparietal sutures appear normal
• no cranial base abnormality is observed at P20
|
|
• at P16 to P21, mice exhibit premature fusion of the coronal sutures unlike in wild-type mice
|
|
• at P16 to P21, mice exhibit premature fusion of the anterior frontal and posterior frontal sutures unlike in wild-type mice
|
|
• at P16 to P21, mice exhibit premature fusion of the saggital sutures unlike in wild-type mice
|
vision/eye
|
• in 12 of 20 mice
|
growth/size/body
long incisors
(
J:63959
)
|
• mice exhibit facial asymmetry with anterio-posterior shortening, lateral widening and vertical heightening compared with wild-type mice
|
|
• mice exhibit midface hypoplasia compared with wild-type mice
|
