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Hmx3tm2Tlu
Targeted Allele Detail
Summary
Symbol: Hmx3tm2Tlu
Name: H6 homeobox 3; targeted mutation 2, Tom Lufkin
MGI ID: MGI:1857541
Synonyms: Hmx3lacZ
Gene: Hmx3  Location: Chr7:131144596-131146654 bp, + strand  Genetic Position: Chr7, 74.32 cM
Alliance: Hmx3tm2Tlu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46379
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA neomycin and lacZ reporter and resistance cassette was inserted into the homeobox sequence of the gene, resulting in the truncation of the protein in the N-terminal portion of the homeodomain. (J:46379)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 52 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmx3 Mutation:  17 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or D3 (129S2/SvPas).
References
Original:  J:46379 Wang W, et al., Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development. 1998 Feb;125(4):621-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory