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Strains, SNPs & Polymorphisms
MGI integrates comparative data on inbred strain characteristics including SNPs, polymorphisms, and quantitative phenotypes.
Access Data
Search for SNPs by strain(s), SNP attributes, genomic position, or associated genes.
SNP Query
Inbred Strains of Mice.
Characteristics of Inbred Strains of Mice and Rats by M. Festing
View lists of Official Mouse Strain Names
View a chart depicting the origins and relationships of inbred mouse strains.
Genealogy Chart of Inbred Strains
Submit data for strains, alleles or phenotypes.
Allele, Strain & Phenotype Submission Form
View guidelines for proper naming of mouse strains.
Guide to Strain Nomenclature
Search for sources of mutant mice and cell lines.
International Mouse Strain Resource (IMSR)
Find information on spontaneous, induced, and genetically-engineered mutations and QTL.
Phenotypes, Alleles & Disease Models
FAQs
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.. find all known coding SNPs in a genomic location for one or more strains? FAQ
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Strains, SNPs & Polymorphisms Includes
23 Sep 2014
15,908,632
RefSNPs
89
Strains with SNPs
10,649
RFLP records
12,035
PCR polymorphism records
More...
MGI-Mouse Strains, SNPs & Polymorphisms: About Strains & SNPs - Strains, SNPs & Polymorphisms: About

Strains

Inbred strains of mice represent unique fixed genotypes that can be repeatedly accessed as homogeneous experimental individuals, with predictable phenotypes and defined allelic composition. Hundreds of inbred strains of mice have been described and new strains continue to be developed, taking advantage of the rich genetic diversity among the existing strains and the ease with which the mouse genome can be manipulated.

MGI serves as a registry for mouse strains worldwide, maintaining the authoritative nomenclature for existing strains. Comparative data on inbred strain characteristics, SNPs, polymorphisms, and quantitative phenotypes are integrated with other genetic, genomic, and biological data in MGI.

SNPs (single nucleotide polymorphisms)

MGI provides comprehensive information about reference SNPs including the reference flanking sequence, assays that define the SNP, and gene/marker associations with their corresponding function class annotations. Each SNP detail page includes links to popular gene browsers including the MGI Mouse Genome Browser.

Other molecular polymorphisms

MGI includes data on RFLP and PCR based polymorphisms. Probes and restriction enzymes used for RFLP analysis and primer sequences used for PCR are provided, with fragment sizes and variants for each strain tested. Links to these data can be found in the Polymorphisms section of gene and marker detail pages.

Strain characteristics and historical origins

MGI holds information on comparative strain characteristics as originally curated by Dr. Michael Festing. These narratives provide key phenotypic traits of major inbred strains, such as behavior, physiology, anatomy, drug responses, immunology, infection, and reproduction. The Genealogy of Inbred Strains provides a "pedigree" of relationships of strains since their origin. The Genealogy Chart graphically displays the movement and development of inbred strains and is particularly useful in looking at dispersion of strains and how inbreeding (and allele fixation) occurred in relation to conserved sequence blocks observed in SNP analysis Data are fully referenced.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory