Sequence Detail

ID/Version

S4R2P9 Q8VHJ8 Q7TS90 (UniProt | EBI)

Last sequence update: 2013-09-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium/calcium exchanger 3;AltName: Full=Na(+)/Ca(2+)-exchange protein 3;AltName: Full=Solute carrier family 8 member 3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 928 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	116	105	3	5

Sequence references in MGI

J:87615 Sokolow S, et al., Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J Clin Invest. 2004 Jan;113(2):265-73
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173357 Molinaro P, et al., Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. J Neurosci. 2011 May 18;31(20):7312-21
J:203079 Boscia F, et al., Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation. Cell Death Differ. 2012 Apr;19(4):562-72
J:213182 Michel LY, et al., Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle. J Biol Chem. 2014 Apr 18;289(16):11293-303
J:225481 Scorziello A, et al., NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death. J Cell Sci. 2013 Dec 15;126(Pt 24):5566-77