Sequence Detail

ID/Version

Q9Z329 Q8R3B0 Q61744 B2KF91 P70226 Q5DWM3 Q5DWM5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 {ECO:0000305};AltName: Full=IP3 receptor isoform 2; Short=IP3R 2; Short=InsP3R2;AltName: Full=Inositol 1,4,5-trisphosphate receptor type 2;AltName: Full=Inositol 1,4,5-

Provider

SWISS-PROT

Sequence

Polypeptide 2701 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itpr2	inositol 1,4,5-triphosphate receptor 2	70	99	3	15

Sequence references in MGI

J:19925 De Smedt H, et al., Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction. J Biol Chem. 1994 Aug 26;269(34):21691-8
J:59593 De Smedt H, et al., Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin. Biochem J. 1997 Mar 1;322(Pt 2):575-83
J:154879 Betzenhauser MJ, et al., Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937. J Biol Chem. 2009 Sep 11;284(37):25116-25
J:164619 Tovey SC, et al., Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. J Biol Chem. 2010 Apr 23;285(17):12979-89
J:217699 Klar J, et al., Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. J Clin Invest. 2014 Nov;124(11):4773-80
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354160 Iwai M, et al., Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J Biol Chem. 2005 Mar 18;280(11):10305-17