Sequence Detail

ID/Version

Q9Z319 B2RRC6 Q566K6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Atrial natriuretic peptide-converting enzyme; EC=3.4.21.-;AltName: Full=Corin;AltName: Full=Low density lipoprotein receptor-related protein 4;AltName: Full=Pro-ANP-converting enzyme;Contains: RecName: Full=Atrial natriuretic peptid

Provider

SWISS-PROT

Sequence

Polypeptide 1113 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Corin	corin, serine peptidase	25	107	3	17

Sequence references in MGI

J:55430 Tomita Y, et al., A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. J Biochem. 1998 Oct;124(4):784-9
J:96458 Chan JC, et al., Hypertension in mice lacking the proatrial natriuretic peptide convertase corin. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):785-90
J:183869 Cui Y, et al., Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012 Apr 12;484(7393):246-50
J:183978 Wu F, et al., Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes. J Biol Chem. 2002 May 10;277(19):16900-5
J:184256 Polzin D, et al., Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases. Kidney Int. 2010 Oct;78(7):650-9
J:185181 Wang W, et al., Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice. Kidney Int. 2012 Jul;82(1):26-33
J:244931 Buckley CL, et al., Corin-deficient W-sh mice poorly tolerate increased cardiac afterload. Regul Pept. 2011 Dec 10;172(1-3):44-50