Sequence Detail

ID/Version

Q9Z309 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Calcium and integrin-binding family member 2;AltName: Full=Kinase-interacting protein 2; Short=KIP 2;

Provider

SWISS-PROT

Sequence

Polypeptide 187 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cib2	calcium and integrin binding family member 2	31	117	3	17

Sequence references in MGI

J:142018 Hager M, et al., Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. J Biol Chem. 2008 Sep 5;283(36):24760-9
J:196222 Riazuddin S, et al., Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet. 2012 Nov;44(11):1265-71
J:244562 Giese APJ, et al., CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017 Jun 29;8(1):43
J:262464 Michel V, et al., CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO Mol Med. 2017 Dec;9(12):1711-1731
J:280151 Wang Y, et al., Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Front Mol Neurosci. 2017;10:401
J:307668 Liang X, et al., CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron. 2021 Jul 7;109(13):2131-2149.e15