Sequence Detail

ID/Version

Q9Z2B9 Q3U3M8 Q91X18 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ribosomal protein S6 kinase alpha-4; Short=S6K-alpha-4; EC=2.7.11.1;AltName: Full=90 kDa ribosomal protein S6 kinase 4;AltName: Full=Nuclear mitogen- and stress-activated protein kinase 2;AltName: Full=RSK-like protein kinase

Provider

SWISS-PROT

Sequence

Polypeptide 773 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rps6ka4	ribosomal protein S6 kinase, polypeptide 4	59	1	3	8

Sequence references in MGI

J:49137 Deak M, et al., Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998 Aug 3;17(15):4426-41
J:97140 Wiggin GR, et al., MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002 Apr;22(8):2871-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139576 Ananieva O, et al., The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 2008 Sep;9(9):1028-36
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89