Sequence Detail

ID/Version

Q9Z2B5 Q9CWT5 Q9CTK8 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3; EC=2.7.11.1 {ECO:0000269|PubMed:9930704};AltName: Full=PRKR-like endoplasmic reticulum kinase;AltName: Full=Pancreatic eIF2-alpha kinase;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1114 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	110	108	3	17

Sequence references in MGI

J:51759 Harding HP, et al., Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase [published erratum appears in Nature 1999 Mar 4;398(6722):90] [see comments]. Nature. 1999 Jan 21;397(6716):271-4
J:99455 Harding HP, et al., Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000 Nov;6(5):1099-108
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:200066 Munoz JP, et al., Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J. 2013 Aug 28;32(17):2348-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89