Sequence Detail

ID/Version

Q9Z2A7 Q9D7Q5 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Diacylglycerol O-acyltransferase 1 {ECO:0000305}; EC=2.3.1.20 {ECO:0000269|PubMed:19028692, ECO:0000269|PubMed:20876538};AltName: Full=Acyl-CoA retinol O-fatty-acyltransferase {ECO:0000303|PubMed:19028692}; Short=ARAT {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 498 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dgat1	diacylglycerol O-acyltransferase 1	63	104	4	19

Sequence references in MGI

J:44983 Cases S, et al., Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13018-23
J:61885 Smith SJ, et al., Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat [see comments]. Nat Genet. 2000 May;25(1):87-90
J:76091 Chen HC, et al., Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest. 2002 Apr;109(8):1049-55
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120436 Buhman KK, et al., DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem. 2002 Jul 12;277(28):25474-9
J:147611 Shih MY, et al., Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13;284(7):4292-9
J:167490 McFie PJ, et al., Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation. J Biol Chem. 2010 Nov 26;285(48):37377-87
J:192630 Eichmann TO, et al., Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30;287(49):41446-57
J:242694 Ma Z, et al., Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. J Lipid Res. 2017 Jun;58(6):1091-1099
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89