Sequence Detail

ID/Version

Q9Z2A0 Q9R215 A6H6U3 Q9R1D8 (UniProt | EBI)

Last sequence update: 2001-10-18
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=3-phosphoinositide-dependent protein kinase 1; Short=mPDK1; EC=2.7.11.1 {ECO:0000269|PubMed:10075713, ECO:0000269|PubMed:16336268, ECO:0000269|PubMed:19047061};

Provider

SWISS-PROT

Sequence

Polypeptide 559 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdpk1	3-phosphoinositide dependent protein kinase 1	82	105	5	176

Sequence references in MGI

J:53564 Dong LQ, et al., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 1999 Mar 19;274(12):8117-22
J:123268 Kelly AP, et al., Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J. 2007 Jul 25;26(14):3441-50
J:134712 Primo L, et al., Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol. 2007 Mar 26;176(7):1035-47
J:146938 Wang C, et al., Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem. 2009 Jan 23;284(4):2038-44
J:150014 Ito K, et al., PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8689-94
J:153548 Westmoreland JJ, et al., Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol. 2009 Oct 1;334(1):285-98
J:163291 Chaurasia B, et al., Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol. 2010 Sep;30(17):4354-66
J:178435 Shumilina E, et al., Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. Cell Physiol Biochem. 2010;26(4-5):699-706
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354163 Bucko-Justyna M, et al., Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. FEBS J. 2005 Dec;272(24):6310-23