Sequence Detail

ID/Version

Q9Z1T6 Q69ZU1 Q9CU94 Q3TNE4 E9QL40 Q3UTT6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=1-phosphatidylinositol 3-phosphate 5-kinase {ECO:0000305}; Short=Phosphatidylinositol 3-phosphate 5-kinase; EC=2.7.1.150 {ECO:0000269|PubMed:10567352};AltName: Full=FYVE finger-containing phosphoinositide kinase;AltName: Full

Provider

SWISS-PROT

Sequence

Polypeptide 2097 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pikfyve	phosphoinositide kinase, FYVE type zinc finger containing	79	102	3	30

Sequence references in MGI

J:51612 Shisheva A, et al., Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol. 1999 Jan;19(1):623-34
J:58829 McEwen RK, et al., Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases. J Biol Chem. 1999 Nov 26;274(48):33905-12
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127106 Zhang Y, et al., Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23
J:135218 Sbrissa D, et al., PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem. 1999 Jul 30;274(31):21589-97
J:142703 Jin N, et al., VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008 Dec 17;27(24):3221-34
J:147603 Ikonomov OC, et al., Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin. J Biol Chem. 2009 Feb 6;284(6):3750-61
J:171129 Ikonomov OC, et al., The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development: PREIMPLANTATION LETHALITY OF PIKfyve-/- EMBRYOS BUT NORMALITY OF PIKfyve+/- MICE. J Biol Chem. 2011 Apr 15;286(15):13404-13
J:199213 Ikonomov OC, et al., Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching. Am J Physiol Endocrinol Metab. 2013 Jul;305(1):E119-31
J:224577 Min SH, et al., Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nat Commun. 2014;5:4691
J:251375 Dayam RM, et al., The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase. J Immunol. 2017 Sep 15;199(6):2096-2105
J:262141 Liggins MC, et al., PIKfyve regulates melanosome biogenesis. PLoS Genet. 2018 Mar;14(3):e1007290
J:289081 Krishna S, et al., PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Dev Cell. 2016 Sep 12;38(5):536-47
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292523 Ikonomov OC, et al., Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. J Biol Chem. 2003 Dec 19;278(51):50863-71
J:292524 Sbrissa D, et al., Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46
J:292526 Sbrissa D, et al., PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation. Biochemistry. 2000 Dec 26;39(51):15980-9
J:292965 Min SH, et al., PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice. Mol Cell Biol. 2019 Nov 1;39(21)