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Sequence Detail
Q9Z1S3 Q8BQP6 Q3URH0 Q3V401 (UniProt | EBI) Last sequence update: 1999-05-01
Last annotation update: 2020-02-26
from provider
RecName: Full=RAS guanyl-releasing protein 1;AltName: Full=Calcium and DAG-regulated guanine nucleotide exchange factor II; Short=CalDAG-GEFII;AltName: Full=Ras guanyl-releasing protein;
Polypeptide 795 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Rasgrp1 RAS guanyl releasing protein 1 47 73 9 15
Sequence references in MGI J:46742 Bottorff D, et al., RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. Mamm Genome. 1999 Apr;10(4):358-61
J:65115 Dower NA, et al., RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol. 2000 Oct;1(4):317-21
J:85189 Layer K, et al., Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity. 2003 Aug;19(2):243-55
J:85616 Priatel JJ, et al., RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. Immunity. 2002 Nov;17(5):617-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108677 Coughlin JJ, et al., RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol. 2005 Dec 1;175(11):7179-84
J:117325 Oki-Idouchi CE, et al., Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. Cancer Res. 2007 Jan 1;67(1):276-80
J:125310 Liu Y, et al., An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med. 2007 Jan 22;204(1):93-103
J:126979 Norment AM, et al., Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes. J Immunol. 2003 Feb 1;170(3):1141-9
J:128295 Beaulieu N, et al., Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane. Mol Biol Cell. 2007 Aug;18(8):3156-68
J:133229 Klinger MB, et al., Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. Oncogene. 2005 Apr 14;24(16):2695-704
J:137980 Priatel JJ, et al., RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development. J Immunol. 2006 Aug 1;177(3):1470-80
J:151230 Priatel JJ, et al., Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15;179(4):2143-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory