Sequence Detail

ID/Version

Q9Z1M0 Q3ULZ7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=P2X purinoceptor 7; Short=P2X7;AltName: Full=ATP receptor;AltName: Full=P2Z receptor;AltName: Full=Purinergic receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 595 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	244	102	3	27

Sequence references in MGI

J:51040 Chessell IP, et al., Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 1998 Nov 13;439(1-2):26-30
J:66835 Solle M, et al., Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem. 2001 Jan 5;276(1):125-32
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:218802 Robinson LE, et al., Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization. J Biol Chem. 2014 Nov 14;289(46):31983-94
J:234520 Yang D, et al., Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. Immunity. 2015 Nov 17;43(5):923-32
J:236350 Karmakar M, et al., Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP. Nat Commun. 2016 Feb 15;7:10555
J:278146 Di A, et al., The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. Immunity. 2018 Jul 17;49(1):56-65.e4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89