Sequence Detail

ID/Version

Q9Z148 Q8K4R6 Q8K4R7 Q9Z149 A2CG75 Q6PE08 (UniProt | EBI)

Last sequence update: 2002-11-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase EHMT2; EC=2.1.1.- {ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:15774718}; EC=2.1.1.367 {ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:15774718};AltName: Full=Euchromatic histone-lysine

Provider

SWISS-PROT

Sequence

Polypeptide 1263 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ehmt2	euchromatic histone lysine N-methyltransferase 2	95	116	3	30

Sequence references in MGI

J:77998 Tachibana M, et al., G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 2002 Jul 15;16(14):1779-91
J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:97244 Tachibana M, et al., Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 2005 Apr 1;19(7):815-26
J:114884 Ueda J, et al., Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. J Biol Chem. 2006 Jul 21;281(29):20120-8
J:143343 Tachibana M, et al., G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J. 2008 Oct 22;27(20):2681-90
J:173043 Kim JK, et al., UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 2009 Feb;37(2):493-505
J:184478 Yu Y, et al., Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. Mol Cell. 2012 Apr 13;46(1):7-17
J:277855 Parvanov ED, et al., PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017 Feb 1;28(3):488-499
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:306882 Kidder BL, et al., SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation. Epigenetics Chromatin. 2017;10:8
J:338223 Wang J, et al., The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells. PLoS One. 2012;7(5):e37647