Sequence Detail

ID/Version

Q9Z132 Q3V1S3 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=R-spondin-1;AltName: Full=Cysteine-rich and single thrombospondin domain-containing protein 3; Short=Cristin-3; Short=mCristin-3;AltName: Full=Roof plate-specific spondin-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 265 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rspo1	R-spondin 1	28	141	3	14

Sequence references in MGI

J:77554 Kamata T, et al., R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 2004 Jan 5;1676(1):51-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113117 Nam JS, et al., Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem. 2006 May 12;281(19):13247-57
J:198905 Carmon KS, et al., R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11452-7
J:222912 Parma P, et al., R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet. 2006 Nov;38(11):1304-9