Sequence Detail

ID/Version

Q9Z0Z3 Q8BSG7 Q99J53 Q8CB22 Q8C8Y9 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=S-phase kinase-associated protein 2;AltName: Full=Cyclin-A/CDK2-associated protein p45;AltName: Full=F-box protein Skp2;AltName: Full=F-box/WD-40 protein 1; Short=FWD1;

Provider

SWISS-PROT

Sequence

Polypeptide 424 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Skp2	S-phase kinase-associated protein 2	61	100	3	37

Sequence references in MGI

J:62130 Nakayama K, et al., Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 2000 May 2;19(9):2069-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:188027 Wu J, et al., Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11;46(3):351-61
J:272605 Liu Y, et al., A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress. Genes Dev. 2018 Nov 1;32(21-22):1380-1397