Sequence Detail

ID/Version

Q9Z0X1 Q1L6K5 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Apoptosis-inducing factor 1, mitochondrial {ECO:0000305}; EC=1.6.99.- {ECO:0000269|PubMed:19447115};AltName: Full=Programmed cell death protein 8;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 612 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	62	111	3	12

Sequence references in MGI

J:52525 Susin SA, et al., Molecular characterization of mitochondrial apoptosis-inducing factor [see comments]. Nature. 1999 Feb 4;397(6718):441-6
J:77719 Yu SW, et al., Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12;297(5579):259-63
J:114356 Delettre C, et al., Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity. J Biol Chem. 2006 Jul 7;281(27):18507-18
J:186001 Wang Y, et al., Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal. 2011;4(167):ra20
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:256078 Hangen E, et al., Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis. Mol Cell. 2015 Jun 18;58(6):1001-14
J:291285 Mashimo M, et al., PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells. JCI Insight. 2019 Feb 21;4(4)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89