Sequence Detail

ID/Version

Q9Z0V2 Q8BSK3 Q8CHB7 Q9JJ60 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Potassium voltage-gated channel subfamily D member 2;AltName: Full=Voltage-gated potassium channel subunit Kv4.2;

Provider

SWISS-PROT

Sequence

Polypeptide 630 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	84	104	3	3

Sequence references in MGI

J:59806 Guo W, et al., Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol. 1999 Dec 15;521 Pt 3:587-99
J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104430 Jinno S, et al., Postsynaptic and extrasynaptic localization of Kv4.2 channels in the mouse hippocampal region, with special reference to targeted clustering at gabaergic synapses. Neuroscience. 2005;134(2):483-94
J:111318 Guo W, et al., Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res. 2005 Dec 9;97(12):1342-50
J:114215 Barry DM, et al., Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res. 1998 Sep 7;83(5):560-7
J:116172 Chen X, et al., Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. J Neurosci. 2006 Nov 22;26(47):12143-51
J:127797 Hu HJ, et al., Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci. 2007 Nov 28;27(48):13181-91
J:159619 Norris AJ, et al., Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010 Apr 7;30(14):5092-101
J:165494 Norris AJ, et al., Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J Neurosci. 2010 Oct 13;30(41):13644-55
J:176403 Nerbonne JM, et al., Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents. J Physiol. 2008 Mar 15;586(6):1565-79
J:184341 Kerti K, et al., Unique somato-dendritic distribution pattern of Kv4.2 channels on hippocampal CA1 pyramidal cells. Eur J Neurosci. 2012 Jan;35(1):66-75
J:186547 Granados-Fuentes D, et al., IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity. J Neurosci. 2012 Jul 18;32(29):10045-52
J:214199 Foeger NC, et al., Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents. J Physiol. 2013 Sep 1;591(Pt 17):4149-66
J:217291 Varga AW, et al., Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain. Learn Mem. 2000 Sep-Oct;7(5):321-32
J:217984 Foeger NC, et al., Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization. J Biol Chem. 2012 Mar 16;287(12):9640-50
J:217990 Marionneau C, et al., Proteomic analyses of native brain K(V)4.2 channel complexes. Channels (Austin). 2009 Jul-Aug;3(4):284-94
J:238462 Burkhalter A, et al., Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses. J Neurosci. 2006 Nov 22;26(47):12274-82
J:245034 Kiselycznyk C, et al., Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors. Biol Mood Anxiety Disord. 2012 Mar 02;2:5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89