Sequence Detail

ID/Version

Q9WVS8 Q5NCN7 Q5NCN6 Q9R1D9 Q5NCN9 Q6QLU8 Q9WVF3 Q3UG52 Q497T0 Q9WVF4 Q3U2N7 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase 7; Short=MAP kinase 7; Short=MAPK 7; EC=2.7.11.24;AltName: Full=Big MAP kinase 1; Short=BMK-1;AltName: Full=Extracellular signal-regulated kinase 5; Short=ERK-5;

Provider

SWISS-PROT

Sequence

Polypeptide 806 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapk7	mitogen-activated protein kinase 7	61	112	3	12

Sequence references in MGI

J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
J:68796 Yan C, et al., Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains. J Biol Chem. 2001 Apr 6;276(14):10870-8
J:89215 Hayashi M, et al., Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest. 2004 Apr;113(8):1138-48
J:96509 McCaw BJ, et al., Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant. Gene. 2005 Jan 31;345(2):183-90
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203314 Erazo T, et al., Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol Cell Biol. 2013 Apr;33(8):1671-86
J:343389 Woo CH, et al., Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010 Dec;24(12):4917-28