Sequence Detail

ID/Version

Q9WVS6 Q9ES22 Q9ES23 Q2KHJ9 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase parkin {ECO:0000305}; EC=2.3.2.31 {ECO:0000250|UniProtKB:O60260};AltName: Full=Parkin RBR E3 ubiquitin-protein ligase {ECO:0000250|UniProtKB:O60260};

Provider

SWISS-PROT

Sequence

Polypeptide 464 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkn	parkin RBR E3 ubiquitin protein ligase	397	100	3	34

Sequence references in MGI

J:62582 Kitada T, et al., Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene. Mamm Genome. 2000 Jun;11(6):417-21
J:73105 Huynh DP, et al., Differential expression and tissue distribution of parkin isoforms during mouse development. Brain Res Dev Brain Res. 2001 Oct 24;130(2):173-81
J:174518 Van Humbeeck C, et al., Parkin interacts with Ambra1 to induce mitophagy. J Neurosci. 2011 Jul 13;31(28):10249-61
J:180609 Kuroda Y, et al., Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. Hum Mol Genet. 2012 Mar 1;21(5):991-1003
J:219122 Yun J, et al., MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife. 2014 Jun 4;3:e01958
J:260099 Wang C, et al., Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology. Nat Commun. 2018 Jan 8;9(1):81
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320008 Ham SJ, et al., Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4281-4291
J:357437 Bhandari P, et al., Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res. 2014 Jan 17;114(2):257-65