Sequence Detail

ID/Version

Q9WVS0 Q9JL17 (UniProt | EBI)

Last sequence update: 2004-07-19
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Inducible T-cell costimulator;AltName: Full=Activation-inducible lymphocyte immunomediatory molecule;AltName: Full=CD28 and CTLA-4-like protein; Short=CCLP;AltName: Full=CD28-related protein 1; Short=CRP-1;AltName: CD_antigen

Provider

SWISS-PROT

Sequence

Polypeptide 200 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Icos	inducible T cell co-stimulator	14	96	2	30

Sequence references in MGI

J:60318 Ling V, et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000 Feb 15;164(4):1653-7
J:61649 Mages HW, et al., Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol. 2000 Apr;30(4):1040-7
J:66702 Tafuri A, et al., ICOS is essential for effective T-helper-cell responses. Nature. 2001 Jan 4;409(6816):105-9
J:87124 McAdam AJ, et al., ICOS is critical for CD40-mediated antibody class switching. Nature. 2001 Jan 4;409(6816):102-5
J:155586 Gigoux M, et al., Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20371-6