Sequence Detail

ID/Version

Q9WVK8 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Cholesterol 24-hydroxylase {ECO:0000305|PubMed:10377398}; Short=CH24H; EC=1.14.14.25 {ECO:0000269|PubMed:10377398};AltName: Full=Cholesterol 24-monooxygenase;AltName: Full=Cholesterol 24S-hydroxylase {ECO:0000303|PubMed:10377

Provider

SWISS-PROT

Sequence

Polypeptide 500 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyp46a1	cytochrome P450, family 46, subfamily a, polypeptide 1	26	109	7	3

Sequence references in MGI

J:56019 Lund EG, et al., cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7238-43
J:107142 Kotti TJ, et al., Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3869-74
J:241374 Mast N, et al., Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. J Biol Chem. 2017 Mar 24;292(12):4913-4924
J:269548 Ramirez DM, et al., Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol. 2008 Apr 10;507(5):1676-93
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89