Sequence Detail

ID/Version

Q9WVF6 Q9JLK0 Q3V4B8 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Group IID secretory phospholipase A2; Short=GIID sPLA2; Short=sPLA2-IID; EC=3.1.1.4 {ECO:0000269|PubMed:10531313};AltName: Full=PLA2IID;AltName: Full=Phosphatidylcholine 2-acylhydrolase 2D;AltName: Full=Secretory-type

Provider

SWISS-PROT

Sequence

Polypeptide 144 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pla2g2d	phospholipase A2, group IID	39	100	2	8

Sequence references in MGI

J:56018 Valentin E, et al., Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. J Biol Chem. 1999 Jul 2;274(27):19152-60
J:57024 Ishizaki J, et al., Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem. 1999 Aug 27;274(35):24973-9
J:58155 Valentin E, et al., On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. J Biol Chem. 1999 Oct 29;274(44):31195-202
J:74678 Koduri RS, et al., Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2). J Biol Chem. 2002 Feb 22;277(8):5849-57
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103142 Shakhov AN, et al., SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. Genes Immun. 2000 Feb;1(3):191-9
J:150812 von Allmen CE, et al., Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11673-8
J:201008 Miki Y, et al., Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. J Exp Med. 2013 Jun 3;210(6):1217-34
J:229035 Vijay R, et al., Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med. 2015 Oct 19;212(11):1851-68
J:235448 Miki Y, et al., Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer. J Biol Chem. 2016 Jul 22;291(30):15588-601