Sequence Detail

ID/Version

Q9WV31 Q9ES15 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Activity-regulated cytoskeleton-associated protein {ECO:0000305}; Short=mArc {ECO:0000303|Ref.2};AltName: Full=Activity-regulated gene 3.1 protein {ECO:0000303|PubMed:11466419}; Short=ARC/ARG3.1 {ECO:0000303|PubMed:11466419};

Provider

SWISS-PROT

Sequence

Polypeptide 396 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Arc	activity regulated cytoskeletal-associated protein	87	106	2	22

Sequence references in MGI

J:61449 Liu D, et al., Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech Dev. 2000 Apr;92(2):207-15
J:81161 Maier B, et al., Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail. Biol Reprod. 2003 Jan;68(1):67-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122964 Shepherd JD, et al., Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron. 2006 Nov 9;52(3):475-84
J:122980 Plath N, et al., Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron. 2006 Nov 9;52(3):437-44
J:143504 Kawashima T, et al., Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):316-21
J:159688 McCurry CL, et al., Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation. Nat Neurosci. 2010 Apr;13(4):450-7
J:167955 Greer PL, et al., The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 5;140(5):704-16
J:178689 Wu J, et al., Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent beta-amyloid generation. Cell. 2011 Oct 28;147(3):615-28
J:201691 Mikuni T, et al., Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron. 2013 Jun 19;78(6):1024-35
J:238944 Manago F, et al., Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia. Cell Rep. 2016 Aug 23;16(8):2116-28
J:259121 Barylko B, et al., Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression. Biochemistry. 2018 Feb 6;57(5):520-524
J:276388 Zhang W, et al., Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation. Mol Cell. 2019 May 23;