Sequence Detail

ID/Version

Q9WUU8 Q922F7 Q9EPP8 Q922A9 Q9R0X3 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TNFAIP3-interacting protein 1;AltName: Full=A20-binding inhibitor of NF-kappa-B activation 1; Short=ABIN; Short=ABIN-1;AltName: Full=Nef-associated factor 1; Short=Naf1;AltName: Full=Virion-associated nuclear shuttlin

Provider

SWISS-PROT

Sequence

Polypeptide 647 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnip1	TNFAIP3 interacting protein 1	34	101	3	72

Sequence references in MGI

J:64942 Heyninck K, et al., The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol. 1999 Jun 28;145(7):1471-82
J:65908 Gupta K, et al., A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions. J Virol. 2000 Dec;74(24):11811-24
J:176826 Nanda SK, et al., Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med. 2011 Jun 6;208(6):1215-28
J:180054 Zhou J, et al., A20-binding inhibitor of NF-kappaB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein beta activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006
J:183962 Wagner S, et al., Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene. 2008 Jun 12;27(26):3739-45
J:186074 Heyninck K, et al., Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett. 2003 Feb 11;536(1-3):135-40
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87