Sequence Detail

ID/Version

Q9WUN2 Q9CT90 Q9DC03 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase TBK1 {ECO:0000305}; EC=2.7.11.1 {ECO:0000269|PubMed:34245780};AltName: Full=T2K {ECO:0000303|Ref.2};AltName: Full=TANK-binding kinase 1 {ECO:0000303|PubMed:10581243};

Provider

SWISS-PROT

Sequence

Polypeptide 729 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tbk1	TANK-binding kinase 1	99	99	3	36

Sequence references in MGI

J:66310 Pomerantz JL, et al., NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999 Dec 1;18(23):6694-704
J:87323 McWhirter SM, et al., IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):233-8
J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50
J:91653 Bonnard M, et al., Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 2000 Sep 15;19(18):4976-85
J:96405 O'Connell RM, et al., Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J Immunol. 2005 Feb 1;174(3):1602-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:245352 Shu C, et al., Structural insights into the functions of TBK1 in innate antimicrobial immunity. Structure. 2013 Jul 02;21(7):1137-48
J:283622 Wang L, et al., Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019 Aug 16;365(6454)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:328512 Tooley AS, et al., The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem. 2021 Jul 8;297(2):100942